European Network Study of Adrenal Tumours for Cancer (ENS@T CANCER) : is a 5-year €6M project that began in 2011. The project was focused on the delivery of a complete virtual research environment for adrenal cancer research and clinical provision. This includes establishment of a range of adrenal tumour databases including adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH)); treatment strategies for patients with different tumour types; the ‘omic data processing associated with biosamples from these patients; imaging analysis for those patients, and support for several large scale clinical trials with cohorts of 2500 patients in each. The ultimate aim of the project was to enhance research in the field of adrenal cancers to improve diagnosis and treatment abilities. The system currently has over 100 cancer centres involved globally; has over 8500 patients (noting that adrenal tumours such as ACC are extremely rare!) and supports over 20 major clinical trials and networks. It is fair to say that the ENS@T CANCER systems have galvanised international research into adrenal tumours. Several follow on projects from ENS@T CANCER have since been funded, e.g. ENSAT-HT.

A multi-center prospective study of biochemical profiles of monoamine-producing tumours: utility for diagnosis and determinants of clinical presentation (PMT study) commenced in 2011 and focused upon the support for a full four phase multi-centre clinical trial involving 2400 patients across Europe with adrenal tumours. The PRESS team established all of the electronic Case Report Forms (eCRFs), the patient databases, the clinical trial processes, the sample management and the underpinning security systems.