Clean Air and Urban Landscapes (CAUL) has been funded ($8.8m) by the Department of the Environment (DotE) as part of the National Environment Science Program (NESP). The mission of the CAUL Hub is to take a comprehensive view of the sustainability and liveability of urban environments. It recognises that clean air and urban landscapes are keys to Australia’s economic prosperity, environmental sustainability and population health. However CAUL recognises that cities are the most complex interactive systems humans have constructed. Any intervention—planting more trees or investing in new transport options—has a range of consequences from the chemical to the political. The PRESS team are involved in the provisioning of the underpinning IT systems that support the integration of data and interworking of the range of research activities more generally. These systems are based around extensions to the AURIN platform to include new data from organisations such as the Bureau of Meteorology and the Environmental Protection Agency.

Agile Simulation of Aircrew Training Continuum (ASATC) is a commercial project funded by the Defence Science and Technology Organisation (DSTO) that runs from October 2015 to June 2017. The focus of this work is in a scheduling system for training and tracking of helicopter pilots required by the defence force of Australia. PRESS are involved in development of an Australia-wide system that can support current and future training needs and demands of helicopter pilots.

Agile Simulation of Aircrew Training Continuum (ASATC) Phase II is a commercial project funded by the Defence Science and Technology Organisation (DSTO) that runs from July 2016 to June 2017. The focus of this work is in extensions and refinements of a scheduling system for training and tracking of helicopter pilots required by the defence forces of Australia. This will provide an Australia-wide system that can support current and future training needs and demands of helicopter pilots in the army, navy and airforce. This work also includes support for mobile applications.

International Disorders of Sex Development (I-DSD): was funded for 5-years (750k€) in 2011 by the UK Medical Research Council to support the continued support of DSD. This system is now used globally and offers a unique resource into rare DSD disorders. A paper describing the output of I-DSD is given here.

European Society for Paediatric Endocrinology (ESPE) Disorder of Sex Development (DSD) Register: was a pilot study (20k€) that explored the creation of a secure internet based register and sharing of a uniform dataset across a group of paediatric endocrine centres across Europe. This proof of concept system was developed in 6 weeks and ultimately resulted in the galvanisation of the DSD community across Europe and the subsequent highly successful EuroDSD project.

Atypical Femur Fractures (AFF) is a clinical data registry that is used for capturing clinical and biomedical data on patients with atypical femur fractures – a rare condition that is often associated with medications that are taken that result in brittle bones. The PRESS team have developed the system and are responsible for the database, eCRFs and associated security demands of the community.

Disorders of Sex Development Network (DSDnet): this COST action focuses on the systematic elucidation of differences of sex development (DSD). It is building a network of all people interested in DSD, from leading scientists to clinicians, as well as people with DSD. Its aim is to obtain new knowledge on the biological pathways of sex development in humans, and to provide information on management for those physicians and psychologists caring for people with DSD. Furthermore, we want to provide a platform for all people with DSD, not only for those seeking medical advice, but also about peer support groups, as well as about the societal and cultural issues around DSD.

EuroRare Diabetes: An EU rare diseases registry for Wolfram, Alstrom and Bardet Biedl syndrome (EuroWABB): is a €1M project which began in 2011 to support European-wide research-oriented collaboration into a range of rare diabetes-related diseases – specifically Wolfram, Alstrom and Bardet Biedl. The work primarily focused upon collaborative networking and data sharing for clinicians dealing with these patients and biomedical researchers wishing to better understand the genetics and molecular mechanisms underlying these diseases. This registry was originally established at the University of Glasgow, but has now been migrated to the University of Melbourne.

European Network Study of Adrenal Tumours for Cancer (ENS@T CANCER) : is a 5-year €6M project that began in 2011. The project was focused on the delivery of a complete virtual research environment for adrenal cancer research and clinical provision. This includes establishment of a range of adrenal tumour databases including adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH)); treatment strategies for patients with different tumour types; the ‘omic data processing associated with biosamples from these patients; imaging analysis for those patients, and support for several large scale clinical trials with cohorts of 2500 patients in each. The ultimate aim of the project was to enhance research in the field of adrenal cancers to improve diagnosis and treatment abilities. The system currently has over 100 cancer centres involved globally; has over 8500 patients (noting that adrenal tumours such as ACC are extremely rare!) and supports over 20 major clinical trials and networks. It is fair to say that the ENS@T CANCER systems have galvanised international research into adrenal tumours. Several follow on projects from ENS@T CANCER have since been funded, e.g. ENSAT-HT.

A multi-center prospective study of biochemical profiles of monoamine-producing tumours: utility for diagnosis and determinants of clinical presentation (PMT study) commenced in 2011 and focused upon the support for a full four phase multi-centre clinical trial involving 2400 patients across Europe with adrenal tumours. The PRESS team established all of the electronic Case Report Forms (eCRFs), the patient databases, the clinical trial processes, the sample management and the underpinning security systems.