Early environmental determinants of pancreatic islet autoimmunity: a pregnancy to early life cohort study in children at risk of type-1 diabetes (ENDIA) was funded ($150k) by the University of Adelaide in 2012 to establish the initial infrastructure for collecting information on pregnant women at risk of having children that go on to develop type-1 diabetes. This system is now used for an extensive range of type-1 diabetes follow on projects (see above).

Diagnostic Manual for the International League Against Epilepsy Classification and Terminology Commission (ILAE) was established in 2012 by the PRESS team. It provides a unique resource for training clinical researchers in the many manifestations of epilepsy. The system developed includes a unique collection of over 100 videos and associated ECGs of individuals (typically children) undergoing the many forms of epileptic events with associated clinical annotations and education materials describing these events and their diagnosis. This resource is now used globally with several thousand doctors and clinicians using this to better understand epilepsy and seizures more generally.

Australian Diabetes Data Network (ADDN) was funded ($2m) by the Juvenile Diabetes Research Foundation (JDRF) and the Australian Paediatric Endocrinology Group (APEG) in April 2013. The project established the first Australia-wide paediatric type-1 diabetes registry. This system includes data extracted from a range of major hospitals/diabetes centres across Australia. PRESS developed the registry and all of the software for processing and extracting the (heterogeneous) data from hospital systems.

An EU rare diseases registry for Niemann-Pick Disease type A, B and C (INPDR) is an international registry that supports research into the rare but typically fatal Niemann-Pick diseases (types A, B and C). Researchers currently use this system across the globe since it provides a critical mass of data on patients (typically children) with Niemann-Pick that hitherto did not exist. The registry including extensive phenotypic/clinical information including treatments, assessments and patient follow up, as well as targeted variant data resources incorporating the first global set of variants associated with Niemann-Pick disease. The system also supports patient self-registration and self-reporting and has resulted in a range of novel mobile applications (games) that can be used for data capture as an artefact of game playing, e.g. by using the accelerometer to measure balance whilst playing games requiring tilting/manipulation of the mobile phone.

Type-1 Diabetes Clinical Trials Research Network (T1DCRN) is a large grant ($7.8m) that has been funded by the Juvenile Diabetes Research Foundation (JDRF) and the Helmsley Charity Trust (HCT). The work commenced in early 2015 and involves supporting a large clinical trial of 1400 pregnant women at risk of having children developing Type-1 Diabetes. In particular the work focuses on the environmental factors that might influence the onset of Type-1 Diabetes. The PRESS team are the sole software providers of the underpinning IT platform for researchers across Australia. This includes the (eCRFs), the databases and the underpinning security. The project runs to the end of 2018.

Centre for Research Excellence in Protection of Pancreatic Beta Cells (CRE-PPBC) is a large multi-centre project funded ($2.5m) by the NHMRC in January 2015. The focus of this CRE is in the factors that are associated with onset of Type 1 diabetes. The PRESS team are the sole software providers of the underpinning IT platform for researchers across Australia. The project runs to the end of 2018.

Combined 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and 123I-Iodometomidate (123I-IMTO) Imaging for Adrenal Neoplasia (FAMIAN Study) is a large multi-centre clinical trial funded by the Dutch Research Foundation as part of the ENSAT-CANCER platform that focuses on a large targeted imaging study. The PRESS team are responsible for all of the IT systems associated with the clinical study including the electronic Case Report Forms (eCRFs), the patient databases, the sample management and the underpinning security systems.

Melbourne Genomics Health Alliance (MGHA) is a large grant ($25m) funded by the Victorian Government. MGHA brings together the clinical, research and teaching strengths among Victoria’s leading hospitals and research organisations, with a vision to deliver genomic medicine into everyday healthcare.

European Research Network in Rare Diseases (ERA-NET) is project funded by the University of Munich, University of Würzburg and Cochin Hospital Paris to support research into rare adrenal cancer diseases. The work is closely connected to the ENSAT-CANCER project. PRESS deliver all of the underlying IT to support these collaborations.

Australian Genomics Health Alliance (AGHA) is a national platform that has been funded by the NHMRC ($25m) and runs from November 2015 to December 2020. AGHA is a national network that seeks to embed genomics data analysis and education into mainstream clinical practice. The work focuses especially on flagship diseases including cancer and rare diseases.